If you want to improve your drug design process, cut down costs and reduce development time we can offer you our services. Our company specialized in the field of search and development of new hits and hit to lead optimization in silico.
Our technology
We have developed original technology to design new bioactive compounds. This technology is based on numerical methods, organic synthesis and biological activity monitoring. The main feature of our technology is the accurate and careful control of any experimental activities using numerical method with immediate feedback. The numerical simulations are based on a distributed cluster of PC (up to 10000 cores). Key features of Didiall, Inc. technique have been patented.
Validation
Our company develops new drug, anticoagulant, Factor Xa inhibitor. Several new original compounds with activity in vitro less than 30nĚ have been synthesized. These compounds are in the stage of optimization for in-house preclinical studies in vivo.
We can be of service to you in:
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Virtual screening: compounds library preparing, target protein preparing, searching of optimal position for each compound against target protein, prediction of biological activity of these compounds, processing and representation of results in Client's preference form.
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De novo drug design: developing of a synthetic approach, starting compounds library preparing, creating of product compounds library, preparing of target protein, searching of optimal position for each compounds against target protein, prediction of biological activity of these compounds, processing and representation of results in Client's preference form, including scheme of synthesis of all potentially active compounds.
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Similarity search: preparation of compounds library, preparation of initial compounds for similarity search, similarity search performing, processing and representation of results in Client's preference form. As an additional option it is possible to include interaction of compounds and target into similarity search.
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Pharmacophore search: preparation of compounds libraries, pharmacophore preparation, pharmacophore searching, processing and representation of results in Client's preference form. As an additional option it is possible to include interaction of compounds and target into pharmacophore search.
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Hit and lead development: searching and developing of hits to Client's target, hit to lead optimization, biological activity monitoring of compounds in vitro, patenting, performing of in-house pre-clinical studies.
Price list:
Service |
Cost |
Duration |
Virtual screening |
From $10.000 |
from 4 weeks |
De novo drug design |
From $20.000 |
from 8 weeks |
Similarity search |
From $20.000 |
from 8 weeks |
Pharmacophore search |
From $20.000 |
from 8 weeks |
Hit and lead development |
Contact us |
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You can download free demo version of structure based drug design software ScoreL 1.1 to try the capability of our original technique.
We hope you are interested in our services. We will be glad to answer any questions.